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Characteristics
Overall (N = 226 Eyes)
Gain ≥ 10 Letters at 1 Year (N = 110 Eyes)
Gain < 10 Letters at 1 Year (N = 116 Eyes)
P Value*
Demographics
Age ≥ 60 years, n (%)
78 (34.5)
30 (27.3)
48 (41.4)
0.041
Male, n (%)
122 (54)
66 (60)
56 (48.3)
0.112
Severe NPDR to PDR stage, n (%)
158 (69.9)
75 (68.2)
83 (71.6)
0.638
Previous macular laser photocoagulation, n (%)
42 (18.6)
13 (11.8)
29 (25)
0.019
Previous PRP, n (%)
63 (27.9)
28 (25.5)
35 (30.2)
0.528
Phakia, n (%)
202 (89.4)
102 (92.7)
100 (86.2)
0.115
Ocular characteristics at baseline
Mean (SD) VA, letter
51.8 (19.1)
46 (21)
57.3 (15.2)
< 0.001
VA ≥ 69 letters, n (%)
63 (27.9)
23 (20.9)
40 (34.5)
0.025
Mean CSFT (SD), µm
496.2 (145.2)
513.9 (164.5)
479.4 (122.6)
0.159
CSFT ≥ 400 µm
163 (72.1)
80 (72.3)
83 (81.6)
0.983
ERM, n (%)
28 (12.4)
7 (6.4)
21 (18.1)
0.012
DRIL, n (%)
65 (28.8)
24 (21.8)
41 (35.3)
0.026
HF, n (%)
99 (43.8)
52 (47.3)
47 (40.5)
0.257
IRC ≥ 600 µm, n (%)
23 (10.2)
9 (8.2)
14 (12.1)
0.399
Disruption of ELM, n (%)
61 (26.9)
30 (27.3)
31 (26.7)
0.858
Disruption of EZ, n (%)
56 (24.8)
18 (16.4)
38 (32.8)
0.003
SRF, n (%)
113 (50)
59 (53.6)
54 (46.6)
0.316
Foveal exudate, n (%)
15 (6.6)
6 (5.5)
9 (7.8)
0.507
Ocular characteristics at week 12
Mean (SD) VA, letter
61.7 (17.8)
63.6 (17.8)
59.9 (17.7)
0.172
VA gain < 5 letters, n (%)
80 (35.4)
13 (11.8)
67 (57.8)
< 0.001
CSFT reduction < 10%, n (%)
78 (34.5)
27 (24.6)
51 (44.0)
0.004
DRIL, n (%)
42 (18.6)
13 (11.8)
29 (25)
0.012
HF, n (%)
63 (27.9)
31 (28.2)
32 (27.6)
0.812
IRC ≥ 600 µm, n (%)
15 (6.6)
4 (3.6)
11 (9.5)
0.046
Disruption of ELM, n (%)
43 (19)
12 (10.9)
31 (26.7)
0.002
Disruption of EZ, n (%)
44 (19.5)
12 (10.9)
32 (27.6)
0.002
SRF, n (%)
41 (18.1)
24 (21.8)
17 (14.7)
0.256
Foveal exudate, n (%)
17 (7.5)
6 (5.5)
11 (9.5)
0.428
During 12 months
Mean (SD) number of injections
7.3 (3.2)
6.9 (3.2)
7.5 (3.2)
0.183
Receiving additional macular laser photocoagulation, n (%)
127 (56.2)
59 (53.6)
68 (58.6)
0.494
VA visual acuity,SD standard deviation, NPDR non-proliferative diabetic retinopathy, PDR proliferative diabetic retinopathy, PRP panretinal photocoagulation, CSFT central subfield thickness, ERM epiretinal membrane, DRIL disorganization of retinal inner layer, HF hyperreflective foci, IRC intraretinal cyst, ELM external limiting membrane, EZ ellipsoid zone, SRF subretinal fluid *generalized estimating equation (GEE)
